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Beverly Hofstadter, is a neuroscientist and world-renowned psychiatrist, his sister is a medical researcher, and his father, Dr. Also, his brother Michael is a Harvard law professor.He is known to be lactose intolerant, and is also known for playing the cello.Sheldon Lee Cooper (Jim Parsons) is a theoretical physicist, possessing a BS, MS, Ph D, a Sc. Originally from East Texas, he was a child prodigy, as he had received his Ph D at age 16.
The series initially centers on five characters: roommates Leonard Hofstadter and Sheldon Cooper, two Caltech physicists; Penny, a waitress and aspiring actress who lives across the hall; and Leonard and Sheldon's friends and co-workers aerospace engineer Howard Wolowitz, and astrophysicist Raj Koothrappali.
He does have a softer side, as he does care about his friends, and loves his mom, grandma, and girlfriend Amy, though he often insults them either about their intellect levels or different opinions.
He shares an apartment in Pasadena with friend and fellow physicist Dr. Sheldon has a deep love and interest for science fiction and comic books, to the point of an obsession, and shows particular affinity for Spock, a fictional character from the Star Trek franchise.
Included among them are parents of the main characters, their dates and their coworkers.
Celebrities such as Stephen Hawking occasionally appear in cameo roles as themselves.